+Search query
-Structure paper
Title | Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 61, Page 2533-2551, Year 2018 |
Publish date | Nov 23, 2017 (structure data deposition date) |
![]() | Rahm, F. / Viklund, J. / Tresaugues, L. / Ellermann, M. / Giese, A. / Ericsson, U. / Forsblom, R. / Ginman, T. / Gunther, J. / Hallberg, K. ...Rahm, F. / Viklund, J. / Tresaugues, L. / Ellermann, M. / Giese, A. / Ericsson, U. / Forsblom, R. / Ginman, T. / Gunther, J. / Hallberg, K. / Lindstrom, J. / Persson, L.B. / Silvander, C. / Talagas, A. / Diaz-Saez, L. / Fedorov, O. / Huber, K.V.M. / Panagakou, I. / Siejka, P. / Gorjanacz, M. / Bauser, M. / Andersson, M. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.55 - 2 Å |
Structure data | ![]() PDB-6f1x: ![]() PDB-6f20: ![]() PDB-6f22: ![]() PDB-6f23: |
Chemicals | ![]() ChemComp-C9Q: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-C9E: ![]() ChemComp-ACT: ![]() ChemComp-GOL: ![]() ChemComp-C9B: ![]() ChemComp-C8Z: |
Source |
|
![]() | HYDROLASE / NUDIX / NUCLEOTIDE HYDROLASE / INHIBITOR / ONCOLOGY |