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Structure paper

TitleStructural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 5079-5089, Year 2018
Publish dateOct 24, 2017 (structure data deposition date)
AuthorsSoliman, C. / Walduck, A.K. / Yuriev, E. / Richards, J.S. / Cywes-Bentley, C. / Pier, G.B. / Ramsland, P.A.
External linksJ. Biol. Chem. / PubMed:29449370
MethodsX-ray diffraction
Resolution1.6 - 1.9 Å
Structure data

PDB-6be2:
Crystal structure of a polysaccharide-binding human Fab (F598)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6be3:
Crystal structure of a polysaccharide-binding human Fab (F598) in complex with N-acetyl-D-glucosamine (GlcNAc)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6be4:
Crystal structure of a polysaccharide-binding human Fab (F598) in complex with nona-N-acetyl-D-glucosamine (9NAc)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin / human antibody / antigen binding fragment / N-acetyl-D-glucosamine / complex / poly-N-acetylglucosamine / oligosaccharide

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