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TitleSurface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.
Journal, issue, pagesCell Rep, Vol. 22, Page 1798-1809, Year 2018
Publish dateJul 5, 2017 (structure data deposition date)
AuthorsKwon, Y.D. / Chuang, G.Y. / Zhang, B. / Bailer, R.T. / Doria-Rose, N.A. / Gindin, T.S. / Lin, B. / Louder, M.K. / McKee, K. / O'Dell, S. ...Kwon, Y.D. / Chuang, G.Y. / Zhang, B. / Bailer, R.T. / Doria-Rose, N.A. / Gindin, T.S. / Lin, B. / Louder, M.K. / McKee, K. / O'Dell, S. / Pegu, A. / Schmidt, S.D. / Asokan, M. / Chen, X. / Choe, M. / Georgiev, I.S. / Jin, V. / Pancera, M. / Rawi, R. / Wang, K. / Chaudhuri, R. / Kueltzo, L.A. / Manceva, S.D. / Todd, J.P. / Scorpio, D.G. / Kim, M. / Reinherz, E.L. / Wagh, K. / Korber, B.M. / Connors, M. / Shapiro, L. / Mascola, J.R. / Kwong, P.D.
External linksCell Rep / PubMed:29444432
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-5wdf:
Crystal structure of 10E8v4-5R+100cF Fab in complex with HIV-1 gp41 peptide
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / HIV-1 neutralizing antibody / MPER / 10E8

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