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TitleHigh-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 1934-1950, Year 2018
Publish dateSep 29, 2017 (structure data deposition date)
AuthorsZhou, H. / Zhou, W. / Zhou, B. / Liu, L. / Chern, T.R. / Chinnaswamy, K. / Lu, J. / Bernard, D. / Yang, C.Y. / Li, S. ...Zhou, H. / Zhou, W. / Zhou, B. / Liu, L. / Chern, T.R. / Chinnaswamy, K. / Lu, J. / Bernard, D. / Yang, C.Y. / Li, S. / Wang, M. / Stuckey, J. / Sun, Y. / Wang, S.
External linksJ. Med. Chem. / PubMed:29438612
MethodsX-ray diffraction
Resolution2.16 Å
Structure data

PDB-6b5q:
DCN1 bound to 38
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsLigase/Inhibitor / E3 ligase / complex / Ligase-Inhibitor complex / LIGASE

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