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Title | Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. |
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Journal, issue, pages | Chem Sci, Vol. 8, Page 7651-7668, Year 2017 |
Publish date | Aug 9, 2017 (structure data deposition date) |
Authors | Yeh, T.L. / Leissing, T.M. / Abboud, M.I. / Thinnes, C.C. / Atasoylu, O. / Holt-Martyn, J.P. / Zhang, D. / Tumber, A. / Lippl, K. / Lohans, C.T. ...Yeh, T.L. / Leissing, T.M. / Abboud, M.I. / Thinnes, C.C. / Atasoylu, O. / Holt-Martyn, J.P. / Zhang, D. / Tumber, A. / Lippl, K. / Lohans, C.T. / Leung, I.K.H. / Morcrette, H. / Clifton, I.J. / Claridge, T.D.W. / Kawamura, A. / Flashman, E. / Lu, X. / Ratcliffe, P.J. / Chowdhury, R. / Pugh, C.W. / Schofield, C.J. |
External links | Chem Sci / PubMed:29435217 |
Methods | X-ray diffraction |
Resolution | 1.99 - 2.45 Å |
Structure data | PDB-5op6: PDB-5op8: PDB-5opc: PDB-5ox5: PDB-5ox6: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-A0W: ChemComp-GOL: ChemComp-HOH: ChemComp-A1H: ChemComp-A1Z: ChemComp-MN: ChemComp-B2E: ChemComp-BCT: |
Source |
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Keywords | OXIDOREDUCTASE / ON-HEME / DIOXYGENASE / OXYGENASE / DNA-BINDING / METAL-BINDING / TRANSCRIPTION / HELIX-LOOP-HELIX-BETA / DSBH / FACIAL TRIAD / ASPARAGINYL/ASPARTYL HYDROXYLASE / EPIGENETIC REGULATION / SIGNALING / ARD / BETA-HYDROXYLATION / ACTIVATOR-INHIBITOR / OXIDOREDUCTASE-PEPTIDE COMPLEX / NON-HEME DIOXYGENASE / IRON / 2-OXOGLUTARATE / HYPOXIA-INDUCIBLE FACTOR / HIF / HIF PROLYL HYDROXYLASE DOMAIN 2 / PHD2 / EGLN1 / HYPOXIA / CYTOPLASM / TRANSCRIPTION/EPIGENETIC REGULATION / DEVELOPMENT / CELL STRUCTURE / TRANSCRIPTION ACTIVATOR/INHIBITOR / UBL CONJUGATION / POLYMORPHISM / VITAMIN C / ZINC-FINGER / FAMILIAL ERYTHROCYTOSIS / BREAST CANCER / TRANSCRIPTION COMPLEX |