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Structure paper

TitleA secondary RET mutation in the activation loop conferring resistance to vandetanib.
Journal, issue, pagesNat Commun, Vol. 9, Page 625-625, Year 2018
Publish dateJan 2, 2018 (structure data deposition date)
AuthorsNakaoku, T. / Kohno, T. / Araki, M. / Niho, S. / Chauhan, R. / Knowles, P.P. / Tsuchihara, K. / Matsumoto, S. / Shimada, Y. / Mimaki, S. ...Nakaoku, T. / Kohno, T. / Araki, M. / Niho, S. / Chauhan, R. / Knowles, P.P. / Tsuchihara, K. / Matsumoto, S. / Shimada, Y. / Mimaki, S. / Ishii, G. / Ichikawa, H. / Nagatoishi, S. / Tsumoto, K. / Okuno, Y. / Yoh, K. / McDonald, N.Q. / Goto, K.
External linksNat Commun / PubMed:29434222
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-6fek:
Oncogenic point mutation of RET receptor tyrosine kinase
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-ADN:
ADENOSINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / tyrosine kinase / oncogene / mutation

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