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TitlePerforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Journal, issue, pagesCell Death Differ., Vol. 25, Page 1517-1529, Year 2018
Publish dateJan 7, 2017 (structure data deposition date)
AuthorsBrennan, A.J. / Law, R.H.P. / Conroy, P.J. / Noori, T. / Lukoyanova, N. / Saibil, H. / Yagita, H. / Ciccone, A. / Verschoor, S. / Whisstock, J.C. ...Brennan, A.J. / Law, R.H.P. / Conroy, P.J. / Noori, T. / Lukoyanova, N. / Saibil, H. / Yagita, H. / Ciccone, A. / Verschoor, S. / Whisstock, J.C. / Trapani, J.A. / Voskoboinik, I.
External linksCell Death Differ. / PubMed:29416110
MethodsX-ray diffraction
Resolution1.8 - 2 Å
Structure data

PDB-5ug6:
Perforin C2 Domain - T431D
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5ug7:
Calcium bound Perforin C2 Domain - T431D
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • mus musculus (house mouse)
KeywordsAPOPTOSIS / C2 / perforin / calcium / proteostasis

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