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| Title | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. |
|---|---|
| Journal, issue, pages | Cell, Vol. 172, Page 578-589.e17, Year 2018 |
| Publish date | Mar 23, 2017 (structure data deposition date) |
 Authors | Janes, M.R. / Zhang, J. / Li, L.S. / Hansen, R. / Peters, U. / Guo, X. / Chen, Y. / Babbar, A. / Firdaus, S.J. / Darjania, L. ...Janes, M.R. / Zhang, J. / Li, L.S. / Hansen, R. / Peters, U. / Guo, X. / Chen, Y. / Babbar, A. / Firdaus, S.J. / Darjania, L. / Feng, J. / Chen, J.H. / Li, S. / Long, Y.O. / Thach, C. / Liu, Y. / Zarieh, A. / Ely, T. / Kucharski, J.M. / Kessler, L.V. / Wu, T. / Yu, K. / Wang, Y. / Yao, Y. / Deng, X. / Zarrinkar, P.P. / Brehmer, D. / Dhanak, D. / Lorenzi, M.V. / Hu-Lowe, D. / Patricelli, M.P. / Ren, P. |
 External links | Cell / PubMed:29373830 |
| Methods | X-ray diffraction |
| Resolution | 1.38 Å |
| Structure data |  PDB-5v9u: |
| Chemicals |  ChemComp-CA:  ChemComp-91S:  ChemComp-GOL:  ChemComp-GDP:  ChemComp-HOH: |
| Source |
|
 Keywords | HYDROLASE/HYDROLASE INHIBITOR / small GTPase domain / covalent inhibitor bound / switch II pocket / GDP bound / HYDROLASE-HYDROLASE INHIBITOR complex |
homo sapiens (human)