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Structure paper

TitleStructural basis of thalidomide enantiomer binding to cereblon
Journal, issue, pagesSci Rep, Vol. 8, Page 1294-1294, Year 2018
Publish dateOct 6, 2017 (structure data deposition date)
AuthorsMori, T. / Ito, T. / Liu, S. / Ando, H. / Sakamoto, S. / Yamaguchi, Y. / Tokunaga, E. / Shibata, N. / Handa, H. / Hakoshima, T.
External linksSci Rep / PubMed:29358579
MethodsX-ray diffraction
Resolution1.8 - 2 Å
Structure data

PDB-5yiz:
Mouse Cereblon thalidomide binding domain complexed with racemic thalidomide
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5yj0:
Mouse Cereblon thalidomide binding domain complexed with S-form thalidomide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-5yj1:
Mouse Cereblon thalidomide binding domain complexed with R-form thalidomide
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-EF2:
S-Thalidomide / medication*YM

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-6EL:
2-[(3~{R})-2,6-bis(oxidanylidene)piperidin-3-yl]isoindole-1,3-dione

Source
  • mus musculus (house mouse)
KeywordsMETAL BINDING PROTEIN / Zinc binding protein

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