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TitleA New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
Journal, issue, pagesJ. Virol., Vol. 92, Year 2018
Publish dateFeb 2, 2018 (structure data deposition date)
AuthorsAbner, E. / Stoszko, M. / Zeng, L. / Chen, H.C. / Izquierdo-Bouldstridge, A. / Konuma, T. / Zorita, E. / Fanunza, E. / Zhang, Q. / Mahmoudi, T. ...Abner, E. / Stoszko, M. / Zeng, L. / Chen, H.C. / Izquierdo-Bouldstridge, A. / Konuma, T. / Zorita, E. / Fanunza, E. / Zhang, Q. / Mahmoudi, T. / Zhou, M.M. / Filion, G.J. / Jordan, A.
External linksJ. Virol. / PubMed:29343578
MethodsNMR (solution)
Structure data

PDB-5z9c:
Solution NMR structures of BRD4 first bromodomain with small compound MMQO
Method: SOLUTION NMR

Chemicals

ChemComp-MQO:
8-methoxy-6-methylquinolin-4(1H)-one

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / BRD4 / bromodomain / inhibitor / HIV / BET / mmqo

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