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-Structure paper
Title | Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 2410-2421, Year 2018 |
Publish date | Dec 14, 2017 (structure data deposition date) |
![]() | Shaw, S. / Bian, Z. / Zhao, B. / Tarr, J.C. / Veerasamy, N. / Jeon, K.O. / Belmar, J. / Arnold, A.L. / Fogarty, S.A. / Perry, E. ...Shaw, S. / Bian, Z. / Zhao, B. / Tarr, J.C. / Veerasamy, N. / Jeon, K.O. / Belmar, J. / Arnold, A.L. / Fogarty, S.A. / Perry, E. / Sensintaffar, J.L. / Camper, D.V. / Rossanese, O.W. / Lee, T. / Olejniczak, E.T. / Fesik, S.W. |
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Methods | X-ray diffraction |
Resolution | 2.75 - 2.9 Å |
Structure data | ![]() PDB-6bw2: ![]() PDB-6bw8: |
Chemicals | ![]() ChemComp-ECY: ![]() ChemComp-HOH: ![]() ChemComp-ECM: |
Source |
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![]() | APOPTOSIS / Mcl-1 inhibitor / cancer / structure-based design / drug discovery |