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Structure paper

TitleStructural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPAR gamma.
Journal, issue, pagesSci Rep, Vol. 8, Page 31-31, Year 2018
Publish dateSep 7, 2017 (structure data deposition date)
AuthorsJang, J.Y. / Bae, H. / Lee, Y.J. / Choi, Y.I. / Kim, H.J. / Park, S.B. / Suh, S.W. / Kim, S.W. / Han, B.W.
External linksSci Rep / PubMed:29311579
MethodsX-ray diffraction
Resolution2 - 2.15 Å
Structure data

PDB-5ycn:
Human PPARgamma ligand binding domain complexed with Lobeglitazone
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-5ycp:
Human PPARgamma ligand binding domain complexed with Rosiglitazone
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-8LX:
(5S)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methyl-amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione / agonist*YM

ChemComp-HOH:
WATER

ChemComp-BRL:
2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PPARgamma / agonist

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