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TitleTrapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction.
Journal, issue, pagesNat Commun, Vol. 9, Page 7-7, Year 2018
Publish dateApr 21, 2017 (structure data deposition date)
AuthorsJabs, F. / Plum, M. / Laursen, N.S. / Jensen, R.K. / Molgaard, B. / Miehe, M. / Mandolesi, M. / Rauber, M.M. / Pfutzner, W. / Jakob, T. ...Jabs, F. / Plum, M. / Laursen, N.S. / Jensen, R.K. / Molgaard, B. / Miehe, M. / Mandolesi, M. / Rauber, M.M. / Pfutzner, W. / Jakob, T. / Mobs, C. / Andersen, G.R. / Spillner, E.
External linksNat Commun / PubMed:29295972
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-5nqw:
IgE-Fc in complex with single domain antibody 026
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / IgE-Fc / nanobody / VHH / allergy

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