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Structure paper

TitleStructure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 507-512, Year 2018
Publish dateDec 3, 2017 (structure data deposition date)
AuthorsTian, L. / Kim, M.S. / Li, H. / Wang, J. / Yang, W.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29295939
MethodsX-ray diffraction
Resolution2.44 - 3.25 Å
Structure data

PDB-6bsg:
Structure of HIV-1 RT complexed with RNA/DNA hybrid in an RNA hydrolysis-off mode
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

PDB-6bsh:
Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode
Method: X-RAY DIFFRACTION / Resolution: 2.649 Å

PDB-6bsi:
Structure of HIV-1 RT complexed with an RNA/DNA hybrid containing the polypurine-tract sequence
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-6bsj:
Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-EFZ:
(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE / medication, antiretroviral*YM

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-TAM:
TRIS(HYDROXYETHYL)AMINOMETHANE / pH buffer*YM

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
  • human immunodeficiency virus type 1 group m subtype b
Keywordsviral protein/dna/rna/inhibitor / HIV-RT / DNA-RNA complex / VIRAL PROTEIN / viral protein-dna-rna complex / viral protein-dna-rna-inhibitor complex / RNase H

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