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TitleDisulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
Journal, issue, pagesAntiviral Res., Vol. 150, Page 155-163, Year 2017
Publish dateJul 28, 2017 (structure data deposition date)
AuthorsLin, M.H. / Moses, D.C. / Hsieh, C.H. / Cheng, S.C. / Chen, Y.H. / Sun, C.Y. / Chou, C.Y.
External linksAntiviral Res. / PubMed:29289665
MethodsX-ray diffraction
Resolution1.65 Å
Structure data

PDB-5y3e:
Crystal structure of SARS coronavirus papain-like protease in complex with glycerol
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-5y3q:
Crystal structure of SARS coronavirus papain-like protease conjugated with beta-mercaptoethanol
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-BME:
BETA-MERCAPTOETHANOL

Source
  • human sars coronavirus
KeywordsHYDROLASE / Complex structure of enzyme with glycerol / complex structure

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