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Structure paper

TitleStructural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Journal, issue, pagesImmunity, Vol. 48, Page 45-58.e6, Year 2018
Publish dateJan 22, 2017 (structure data deposition date)
AuthorsBloch, Y. / Bouchareychas, L. / Merceron, R. / Skladanowska, K. / Van den Bossche, L. / Detry, S. / Govindarajan, S. / Elewaut, D. / Haerynck, F. / Dullaers, M. ...Bloch, Y. / Bouchareychas, L. / Merceron, R. / Skladanowska, K. / Van den Bossche, L. / Detry, S. / Govindarajan, S. / Elewaut, D. / Haerynck, F. / Dullaers, M. / Adamopoulos, I.E. / Savvides, S.N.
External linksImmunity / PubMed:29287995
MethodsX-ray diffraction
Resolution2.219 - 3.9 Å
Structure data

PDB-5mxa:
Structure of unbound Interleukin-23
Method: X-RAY DIFFRACTION / Resolution: 2.501 Å

PDB-5mzv:
IL-23:IL-23R:Nb22E11 complex
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5n2k:
Structure of unbound Briakinumab FAb
Method: X-RAY DIFFRACTION / Resolution: 2.219 Å

PDB-5njd:
Structure of Interleukin 23 in complex with Briakinumab FAb
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsCYTOKINE / extracellular / inflammation / Fibronectin type III / IMMUNE SYSTEM / antagonist / antibody / extracellular region

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