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Structure paper

TitleDouble mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.
Journal, issue, pagesNat Commun, Vol. 8, Page 2281-2281, Year 2017
Publish dateMar 13, 2017 (structure data deposition date)
AuthorsSong, Y. / Zhou, H. / Vo, M.N. / Shi, Y. / Nawaz, M.H. / Vargas-Rodriguez, O. / Diedrich, J.K. / Yates, J.R. / Kishi, S. / Musier-Forsyth, K. / Schimmel, P.
External linksNat Commun / PubMed:29273753
MethodsX-ray diffraction
Resolution2.03 - 2.59 Å
Structure data

PDB-5v58:
Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-5v59:
Crystal structure of catalytic fragment of human AlaRS in complex with Aze-SA
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-8X1:
5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / aminoacyl-tRNA synthetase / non-proteinogenic amino acids / Non-proteinogenic amino acid

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