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-Structure paper
タイトル | Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. U.S.A., Vol. 115, Page E72-E81, Year 2018 |
掲載日 | 2016年12月6日 (構造データの登録日) |
![]() | Robinson, J.I. / Baxter, E.W. / Owen, R.L. / Thomsen, M. / Tomlinson, D.C. / Waterhouse, M.P. / Win, S.J. / Nettleship, J.E. / Tiede, C. / Foster, R.J. ...Robinson, J.I. / Baxter, E.W. / Owen, R.L. / Thomsen, M. / Tomlinson, D.C. / Waterhouse, M.P. / Win, S.J. / Nettleship, J.E. / Tiede, C. / Foster, R.J. / Owens, R.J. / Fishwick, C.W.G. / Harris, S.A. / Goldman, A. / McPherson, M.J. / Morgan, A.W. |
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手法 | X線回折 |
解像度 | 2.35 Å |
構造データ | ![]() PDB-5ml9: ![]() PDB-5mn2: |
化合物 | ![]() ChemComp-NAG: ![]() ChemComp-SO4: ![]() ChemComp-PEG: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-GOL: ![]() ChemComp-PG4: |
由来 |
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![]() | IMMUNE SYSTEM / Fc gamma receptor IIIa Affimer Competitive inhibitor FCGR3A / Fc gamma receptor IIIa Affimer Allosteric inhibitor FCGR3A |