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TitleH3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Journal, issue, pagesCancer Res., Vol. 77, Page 6999-7013, Year 2017
Publish dateApr 30, 2017 (structure data deposition date)
AuthorsJoshi, J.J. / Coffey, H. / Corcoran, E. / Tsai, J. / Huang, C.L. / Ichikawa, K. / Prajapati, S. / Hao, M.H. / Bailey, S. / Wu, J. ...Joshi, J.J. / Coffey, H. / Corcoran, E. / Tsai, J. / Huang, C.L. / Ichikawa, K. / Prajapati, S. / Hao, M.H. / Bailey, S. / Wu, J. / Rimkunas, V. / Karr, C. / Subramanian, V. / Kumar, P. / MacKenzie, C. / Hurley, R. / Satoh, T. / Yu, K. / Park, E. / Rioux, N. / Kim, A. / Lai, W.G. / Yu, L. / Zhu, P. / Buonamici, S. / Larsen, N. / Fekkes, P. / Wang, J. / Warmuth, M. / Reynolds, D.J. / Smith, P.G. / Selvaraj, A.
External linksCancer Res. / PubMed:29247039
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-5vnd:
Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-9ES:
N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstransferase/transferase inhibitor / FGFR4 / H3B-56527 / Covalent compound / transferase-transferase inhibitor complex

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