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Title | Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 1031-1044, Year 2018 |
Publish date | Aug 17, 2017 (structure data deposition date) |
![]() | Dohle, W. / Jourdan, F.L. / Menchon, G. / Prota, A.E. / Foster, P.A. / Mannion, P. / Hamel, E. / Thomas, M.P. / Kasprzyk, P.G. / Ferrandis, E. ...Dohle, W. / Jourdan, F.L. / Menchon, G. / Prota, A.E. / Foster, P.A. / Mannion, P. / Hamel, E. / Thomas, M.P. / Kasprzyk, P.G. / Ferrandis, E. / Steinmetz, M.O. / Leese, M.P. / Potter, B.V.L. |
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Methods | X-ray diffraction |
Resolution | 2.11 Å |
Structure data | ![]() PDB-5osk: |
Chemicals | ![]() ChemComp-GTP: ![]() ChemComp-MG: ![]() ChemComp-GOL: ![]() ChemComp-GDP: ![]() ChemComp-MES: ![]() ChemComp-A9Q: ![]() ChemComp-CA: ![]() ChemComp-IMD: ![]() ChemComp-ACP: ![]() ChemComp-HOH: |
Source |
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![]() | CELL CYCLE / TUBULIN FOLD / CYTOSKELETON / MICROTUBULE QUINAZOLINONES |