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Structure paper

TitleDual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Journal, issue, pagesFront Immunol, Vol. 8, Page 1503-1503, Year 2017
Publish dateApr 5, 2017 (structure data deposition date)
AuthorsCole, D.K. / Fuller, A. / Dolton, G. / Zervoudi, E. / Legut, M. / Miles, K. / Blanchfield, L. / Madura, F. / Holland, C.J. / Bulek, A.M. ...Cole, D.K. / Fuller, A. / Dolton, G. / Zervoudi, E. / Legut, M. / Miles, K. / Blanchfield, L. / Madura, F. / Holland, C.J. / Bulek, A.M. / Bridgeman, J.S. / Miles, J.J. / Schauenburg, A.J.A. / Beck, K. / Evavold, B.D. / Rizkallah, P.J. / Sewell, A.K.
External linksFront Immunol / PubMed:29209312
MethodsX-ray diffraction
Resolution1.55 - 2.94 Å
Structure data

PDB-5nmd:
868 TCR Specific for HLA A02 presenting HIV Epitope SLYNTVATL
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-5nme:
868 TCR in complex with HLA A02 presenting SLYNTVATL
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

PDB-5nmf:
868 TCR in complex with HLA A02 presenting SLYNTIATL
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

PDB-5nmg:
868 TCR in complex with HLA A02 presenting SLYFNTIAVL
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-5nmh:
HLA A02 presenting SLYNTIATL
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-5nmk:
HLA A02 presenting SLFNTIAVL
Method: X-RAY DIFFRACTION / Resolution: 1.66 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / MHC / TCR / CD8+

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