タイトル Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design. ジャーナル・号・ページ Insect Biochem. Mol. Biol. , Vol. 92, Page 84-92, Year 2017掲載日 2017年9月13日 (構造データの登録日) 著者Picard, M.E. / Nisole, A. / Beliveau, C. / Sen, S. / Barbar, A. / Shi, R. / Cusson, M. リンク Insect Biochem. Mol. Biol. / PubMed:29183817手法 X線回折 解像度 1.83 - 2.82 Å 構造データ PDB-6b02 : 構造ビューア Crystal structure of CfFPPS2 (apo form), a lepidopteran type-II farnesyl diphosphate synthase 手法 : X-RAY DIFFRACTION / 解像度 : 2.82 Å
PDB-6b04 : 構造ビューア Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b) 手法 : X-RAY DIFFRACTION / 解像度 : 1.83 Å
PDB-6b06 : 構造ビューア Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with IPP and [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)手法 : X-RAY DIFFRACTION / 解像度 : 2.6 Å
PDB-6b07 : 構造ビューア Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [1-phosphono-2-(1-propylpyridin-2-yl)ethyl]phosphonic acid (inhibitor 1d) 手法 : X-RAY DIFFRACTION / 解像度 : 1.98 Å
化合物 ChemComp-C6J : 構造ビューア [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid
ChemComp-C6M : 構造ビューア [1-phosphono-2-(1-propylpyridin-2-yl)ethyl]phosphonic acid
由来 choristoneura fumiferana (蝶・蛾) キーワード TRANSFERASE / juvenile hormone / farnesyl diphosphate synthase / TRANSFERASE/TRANSFERASE INHIBITOR / inhibitor design / TRANSFERASE-TRANSFERASE INHIBITOR complex