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-Structure paper
Title | Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 10071-10091, Year 2017 |
Publish date | May 25, 2016 (structure data deposition date) |
![]() | Scott, J.S. / Degorce, S.L. / Anjum, R. / Culshaw, J. / Davies, R.D.M. / Davies, N.L. / Dillman, K.S. / Dowling, J.E. / Drew, L. / Ferguson, A.D. ...Scott, J.S. / Degorce, S.L. / Anjum, R. / Culshaw, J. / Davies, R.D.M. / Davies, N.L. / Dillman, K.S. / Dowling, J.E. / Drew, L. / Ferguson, A.D. / Groombridge, S.D. / Halsall, C.T. / Hudson, J.A. / Lamont, S. / Lindsay, N.A. / Marden, S.K. / Mayo, M.F. / Pease, J.E. / Perkins, D.R. / Pink, J.H. / Robb, G.R. / Rosen, A. / Shen, M. / McWhirter, C. / Wu, D. |
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Methods | X-ray diffraction |
Resolution | 2.03 - 2.74 Å |
Structure data | ![]() PDB-5k72: ![]() PDB-5k75: ![]() PDB-5k76: ![]() PDB-5k7g: ![]() PDB-5k7i: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-6QY: ![]() ChemComp-HOH: ![]() ChemComp-6QX: ![]() ChemComp-6R1: ![]() ChemComp-6R0: ![]() ChemComp-6QZ: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Inhibitor / Kinase / Protein tyrosine kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |