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TitleMolecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance.
Journal, issue, pagesMol. Cancer Ther., Vol. 17, Page 521-531, Year 2018
Publish dateSep 23, 2017 (structure data deposition date)
AuthorsBagchi, A. / Haidar, J.N. / Eastman, S.W. / Vieth, M. / Topper, M. / Iacolina, M.D. / Walker, J.M. / Forest, A. / Shen, Y. / Novosiadly, R.D. / Ferguson, K.M.
External linksMol. Cancer Ther. / PubMed:29158469
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-6b3s:
Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/immune system / Therapeutic antibody / Cetuximab resistance / Somatic mutation / Colorectal cancer / TRANSFERASE / TRANSFERASE-immune system complex

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