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Structure paper

TitleAllosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 10205-10219, Year 2017
Publish dateJul 13, 2017 (structure data deposition date)
AuthorsXie, J. / Si, X. / Gu, S. / Wang, M. / Shen, J. / Li, H. / Li, D. / Fang, Y. / Liu, C. / Zhu, J.
External linksJ. Med. Chem. / PubMed:29155585
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-5xzr:
The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-8J6:
4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / phosphatase / SH2 domain / allosteric inhibitor / cancer / SIGNALING PROTEIN

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