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TitleBinding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.
Journal, issue, pagesNat Commun, Vol. 8, Page 1476-1476, Year 2017
Publish dateAug 14, 2017 (structure data deposition date)
AuthorsSivaramakrishnan, M. / McCarthy, K.D. / Campagne, S. / Huber, S. / Meier, S. / Augustin, A. / Heckel, T. / Meistermann, H. / Hug, M.N. / Birrer, P. ...Sivaramakrishnan, M. / McCarthy, K.D. / Campagne, S. / Huber, S. / Meier, S. / Augustin, A. / Heckel, T. / Meistermann, H. / Hug, M.N. / Birrer, P. / Moursy, A. / Khawaja, S. / Schmucki, R. / Berntenis, N. / Giroud, N. / Golling, S. / Tzouros, M. / Banfai, B. / Duran-Pacheco, G. / Lamerz, J. / Hsiu Liu, Y. / Luebbers, T. / Ratni, H. / Ebeling, M. / Clery, A. / Paushkin, S. / Krainer, A.R. / Allain, F.H. / Metzger, F.
External linksNat Commun / PubMed:29133793
MethodsNMR (solution)
Structure data

PDB-5or0:
NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA
Method: SOLUTION NMR

Source
  • homo sapiens (human)
KeywordsRNA / 5'-splice site / SMN2 / Small muscular atrophy

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