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TitleProtein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 12460-12465, Year 2017
Publish dateFeb 9, 2017 (structure data deposition date)
AuthorsGetschman, A.E. / Imai, Y. / Larsen, O. / Peterson, F.C. / Wu, X. / Rosenkilde, M.M. / Hwang, S.T. / Volkman, B.F.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29109267
MethodsX-ray diffraction
Resolution2.0004 Å
Structure data

PDB-5ur7:
Crystal structure of engineered CCL20 disulfide locked dimer
Method: X-RAY DIFFRACTION / Resolution: 2.0004 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CCL20 / chemokine / Macrophage Inflammatory Protein-3 alpha / MIP3-alpha / chemotaxis / psoriasis / locked dimer / cytokine

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