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TitleGeneral and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Journal, issue, pagesCell Chem Biol, Vol. 24, Page 1523-1536.e4, Year 2017
Publish dateJan 6, 2017 (structure data deposition date)
AuthorsTicha, A. / Stanchev, S. / Vinothkumar, K.R. / Mikles, D.C. / Pachl, P. / Began, J. / Skerle, J. / Svehlova, K. / Nguyen, M.T.N. / Verhelst, S.H.L. ...Ticha, A. / Stanchev, S. / Vinothkumar, K.R. / Mikles, D.C. / Pachl, P. / Began, J. / Skerle, J. / Svehlova, K. / Nguyen, M.T.N. / Verhelst, S.H.L. / Johnson, D.C. / Bachovchin, D.A. / Lepsik, M. / Majer, P. / Strisovsky, K.
External linksCell Chem Biol / PubMed:29107700
MethodsX-ray diffraction
Resolution1.79 - 2.16 Å
Structure data

PDB-5mt6:
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

PDB-5mt7:
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-5mt8:
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-cmk
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-5mtf:
A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-BNG:
nonyl beta-D-glucopyranoside / detergent*YM

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • escherichia coli k-12 (bacteria)
  • providencia stuartii (bacteria)
  • escherichia coli o45:k1 (strain s88 / expec) (bacteria)
  • synthetic construct (others)
KeywordsHYDROLASE / Membrane protein / Intramembrane protease / Rhomboid protease / specificity / inhibition / ketoamide

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