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Structure paper

TitleStructure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Journal, issue, pagesNat Commun, Vol. 8, Page 1287-1287, Year 2017
Publish dateJul 13, 2017 (structure data deposition date)
AuthorsBoniecki, M.T. / Freibert, S.A. / Muhlenhoff, U. / Lill, R. / Cygler, M.
External linksNat Commun / PubMed:29097656
MethodsX-ray diffraction
Resolution2.75 - 3.317 Å
Structure data

PDB-5wgb:
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and E. coli ACP1 protein at 2.75A
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-5wkp:
Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-5wlw:
Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.
Method: X-RAY DIFFRACTION / Resolution: 3.317 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-8Q1:
S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • escherichia coli o45:k1 (strain s88 / expec) (bacteria)
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / Human mitochondrial cysteine desulfurse LYR Motif containing protein 4 Acyl Carrier Protein 1 (E.coli) / Human mitochondrial cysteine desulfurse LYR Motif containing protein 4 Iron-Sulfur Cluster Scaffold Protein ISCU1 Acyl Carrier Protein 1 (E.coli) / Human mitochondrial cysteine desulfurse LYR Motif containing protein 4 Iron-Sulfur Cluster Scaffold Protein ISCU1 with Zn in the active site Acyl Carrier Protein 1 (E.coli)

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