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TitleThe X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.
Journal, issue, pagesMol. Pharmacol., Vol. 93, Page 14-24, Year 2018
Publish dateApr 5, 2017 (structure data deposition date)
AuthorsHsu, M.H. / Savas, U. / Johnson, E.F.
External linksMol. Pharmacol. / PubMed:29093019
MethodsX-ray diffraction
Resolution2.91 Å
Structure data

PDB-5veu:
Human Cytochrome P450 3A5 (CYP3A5)
Method: X-RAY DIFFRACTION / Resolution: 2.91 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-RIT:
RITONAVIR / medication, antiretroviral*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE inhibitor / Inhibitor / Complex / Cytochrome P450 / ritonavir / CYP3A5 / OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex

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