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TitleSubstrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
Journal, issue, pagesFASEB J., Vol. 32, Page 1085-1098, Year 2018
Publish dateOct 17, 2017 (structure data deposition date)
AuthorsWei, P. / Song, G. / Shi, M. / Zhou, Y. / Liu, Y. / Lei, J. / Chen, P. / Yin, L.
External linksFASEB J. / PubMed:29079699
MethodsX-ray diffraction
Resolution1.5 - 1.85 Å
Structure data

PDB-5ylc:
Crystal Structure of MCR-1 Catalytic Domain
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-5yle:
MCR-1 complex with ethanolamine (ETA)
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-5ylf:
MCR-1 complex with D-glucose
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ETA:
ETHANOLAMINE

ChemComp-BGC:
beta-D-glucopyranose

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / Phosphoethanolamine Transferase / plasmid-mediated transferable colistin resistance gene

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