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TitleStructure of Human M-type Phospholipase A2 Receptor Revealed by Cryo-Electron Microscopy.
Journal, issue, pagesJ Mol Biol, Vol. 429, Issue 24, Page 3825-3835, Year 2017
Publish dateDec 8, 2017
AuthorsYue Dong / Longxing Cao / Hua Tang / Xiangyi Shi / Yongning He /
PubMed AbstractM-type phospholipase A2 receptor (M-PLA2R) is a member of the mannose receptor family and known as the receptor of secretory phospholipase A2s. It has also been identified as the major autoantigen of ...M-type phospholipase A2 receptor (M-PLA2R) is a member of the mannose receptor family and known as the receptor of secretory phospholipase A2s. It has also been identified as the major autoantigen of idiopathic membranous nephropathy, one of the most common causes for nephrotic syndrome in adults. Here we determine the structure of human M-PLA2R ectodomain by cryo-electron microscopy. The results show that the ectodomain has high internal flexibility and forms a compact dual-ring-shaped conformation at acidic pH and adopts extended conformations at basic pH. The inter-domain interactions of human M-PLA2R are explored by the binding studies with individual domains, showing the mechanism of the conformational change. In addition, the biochemical data suggest that mouse M-PLA2R recognizes mouse secretory phospholipase A2-G1B only at physiological or basic pH, rather than at acidic pH. These results suggest that the pH-dependent conformational change might play important roles in the functional activities of M-PLA2R such as ligand binding and release, and may also be relevant to the immunogenicity in membranous nephropathy.
External linksJ Mol Biol / PubMed:29079480
MethodsEM (single particle)
Resolution10.0 Å
Structure data

EMDB-6806:
Class2 cryoEM structure of human M-type phospholipase A2 receptor
Method: EM (single particle) / Resolution: 10.0 Å

EMDB-6807:
Class3 cryoEM structure of human M-type phospholipase A2 receptor
Method: EM (single particle) / Resolution: 10.0 Å

EMDB-6808:
Class1 cryoEM structure of human M-type phospholipase A2 receptor
Method: EM (single particle) / Resolution: 10.0 Å

Source
  • Homo sapiens (human)

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