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Structure paper

TitleThe Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.
Journal, issue, pagesJ. Immunol., Vol. 199, Page 3883-3891, Year 2017
Publish dateDec 20, 2016 (structure data deposition date)
AuthorsPang, S.S. / Wijeyewickrema, L.C. / Hor, L. / Tan, S. / Lameignere, E. / Conway, E.M. / Blom, A.M. / Mohlin, F.C. / Liu, X. / Payne, R.J. ...Pang, S.S. / Wijeyewickrema, L.C. / Hor, L. / Tan, S. / Lameignere, E. / Conway, E.M. / Blom, A.M. / Mohlin, F.C. / Liu, X. / Payne, R.J. / Whisstock, J.C. / Pike, R.N.
External linksJ. Immunol. / PubMed:29061764
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-5ubm:
Crystal structure of human C1s in complex with inhibitor gigastasin
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • haementeria ghilianii (Amazon leech)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM/INHIBITOR / Complement system C1s protease inhibitor complex / IMMUNE SYSTEM-INHIBITOR complex

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