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TitleTargeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.
Journal, issue, pagesStructure, Vol. 25, Page 1719-1731.e4, Year 2017
Publish dateJun 12, 2017 (structure data deposition date)
AuthorsTolbert, W.D. / Gohain, N. / Alsahafi, N. / Van, V. / Orlandi, C. / Ding, S. / Martin, L. / Finzi, A. / Lewis, G.K. / Ray, K. / Pazgier, M.
External linksStructure / PubMed:29056481
MethodsX-ray diffraction
Resolution2.92 Å
Structure data

PDB-5w4l:
Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5.
Method: X-RAY DIFFRACTION / Resolution: 2.92 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 gp120 / Clade A/E 93TH057 / Viral protein / Viral protein-immune system complex

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