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Title | A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. |
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Journal, issue, pages | Elife, Vol. 6, Year 2017 |
Publish date | Nov 21, 2016 (structure data deposition date) |
Authors | Aoki, M. / Hayashi, H. / Rao, K.V. / Das, D. / Higashi-Kuwata, N. / Bulut, H. / Aoki-Ogata, H. / Takamatsu, Y. / Yedidi, R.S. / Davis, D.A. ...Aoki, M. / Hayashi, H. / Rao, K.V. / Das, D. / Higashi-Kuwata, N. / Bulut, H. / Aoki-Ogata, H. / Takamatsu, Y. / Yedidi, R.S. / Davis, D.A. / Hattori, S.I. / Nishida, N. / Hasegawa, K. / Takamune, N. / Nyalapatla, P.R. / Osswald, H.L. / Jono, H. / Saito, H. / Yarchoan, R. / Misumi, S. / Ghosh, A.K. / Mitsuya, H. |
External links | Elife / PubMed:29039736 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.007 Å |
Structure data | PDB-5tyr: PDB-5tys: |
Chemicals | ChemComp-7O7: ChemComp-HOH: ChemComp-7OA: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / GRL-121 / HIV-1 PROTEASE / PROTEASE-INHIBITOR / DARUNAVIR / PYRAN / FURAN / NONPEPTIDIC / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / AIDS / GRL-142 |