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TitleStructure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 8982-8988, Year 2017
Publish dateApr 28, 2016 (structure data deposition date)
AuthorsKruger, D.M. / Glas, A. / Bier, D. / Pospiech, N. / Wallraven, K. / Dietrich, L. / Ottmann, C. / Koch, O. / Hennig, S. / Grossmann, T.N.
External linksJ. Med. Chem. / PubMed:29028171
MethodsX-ray diffraction
Resolution2.34 Å
Structure data

PDB-5jm4:
Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

Chemicals

ChemComp-BEZ:
BENZOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN / peptidomimetic / PPI inhibitor / macrocycle

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