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TitleSynthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 8482-8514, Year 2017
Publish dateOct 8, 2017 (structure data deposition date)
AuthorsWagman, A.S. / Boyce, R.S. / Brown, S.P. / Fang, E. / Goff, D. / Jansen, J.M. / Le, V.P. / Levine, B.H. / Ng, S.C. / Ni, Z.J. ...Wagman, A.S. / Boyce, R.S. / Brown, S.P. / Fang, E. / Goff, D. / Jansen, J.M. / Le, V.P. / Levine, B.H. / Ng, S.C. / Ni, Z.J. / Nuss, J.M. / Pfister, K.B. / Ramurthy, S. / Renhowe, P.A. / Ring, D.B. / Shu, W. / Subramanian, S. / Zhou, X.A. / Shafer, C.M. / Harrison, S.D. / Johnson, K.W. / Bussiere, D.E.
External linksJ. Med. Chem. / PubMed:29016121
MethodsX-ray diffraction
Resolution2.595 Å
Structure data

PDB-6b8j:
Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.595 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-65C:
CHIR99021 / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE Inhibitor / kinase / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex

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