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Structure paper

TitleStructural basis for GABAA receptor potentiation by neurosteroids.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 24, Page 986-992, Year 2017
Publish dateJun 13, 2017 (structure data deposition date)
AuthorsMiller, P.S. / Scott, S. / Masiulis, S. / De Colibus, L. / Pardon, E. / Steyaert, J. / Aricescu, A.R.
External linksNat. Struct. Mol. Biol. / PubMed:28991263
MethodsX-ray diffraction
Resolution3.2 - 3.3 Å
Structure data

PDB-5o8f:
Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25 and pregnanolone
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-5ojm:
Structure of a chimaeric beta3-alpha5 GABAA receptor in complex with nanobody Nb25
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-P9N:
Pregnanolone / inhibitor*YM

Source
  • homo sapiens (human)
  • lama glama (llama)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / GABAA receptor / Pregnanolone / Nanobody complex / Neurosteroid / Ion channel

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