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TitlePredicting allosteric mutants that increase activity of a major antibiotic resistance enzyme.
Journal, issue, pagesChem Sci, Vol. 8, Page 6484-6492, Year 2017
Publish dateJun 27, 2016 (structure data deposition date)
AuthorsLatallo, M.J. / Cortina, G.A. / Faham, S. / Nakamoto, R.K. / Kasson, P.M.
External linksChem Sci / PubMed:28989673
MethodsX-ray diffraction
Resolution1.7 - 1.8 Å
Structure data

PDB-5kmt:
CTX-M9 mutant L48A
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5kmu:
CTX-M-9 beta lactamase mutant - T165W
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / beta lactamase / ESBL

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