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TitleMechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa.
Journal, issue, pagesChem. Res. Toxicol., Vol. 30, Page 2023-2032, Year 2017
Publish dateJun 6, 2017 (structure data deposition date)
AuthorsYockey, O.P. / Jha, V. / Ghodke, P.P. / Xu, T. / Xu, W. / Ling, H. / Pradeepkumar, P.I. / Zhao, L.
External linksChem. Res. Toxicol. / PubMed:28972744
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-5w2a:
Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dCMPNPP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5w2c:
Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dAMPNPP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-0KX:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-DZ4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

Source
  • homo sapiens (human)
  • unidentified (others)
KeywordsREPLICATION / Translesion synthesis / Lucidin-derived DNA adduct / DNA polymerase kappa / mutagenesis

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