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TitleResistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 19814-19825, Year 2017
Publish dateApr 26, 2016 (structure data deposition date)
AuthorsHoyte, A.C. / Jamin, A.V. / Koneru, P.C. / Kobe, M.J. / Larue, R.C. / Fuchs, J.R. / Engelman, A.N. / Kvaratskhelia, M.
External linksJ. Biol. Chem. / PubMed:28972144
MethodsX-ray diffraction
Resolution1.758 Å
Structure data

PDB-5jl4:
Inhibitor resistant mutant catalytic core domain of HIV-1 Integrase
Method: X-RAY DIFFRACTION / Resolution: 1.758 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsDNA BINDING PROTEIN / Allini HIV Integrase Multimerization

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