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Title | Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 4925-4931, Year 2017 |
Publish date | Jul 27, 2017 (structure data deposition date) |
![]() | Ghosh, A.K. / Sean Fyvie, W. / Brindisi, M. / Steffey, M. / Agniswamy, J. / Wang, Y.F. / Aoki, M. / Amano, M. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.27 Å |
Structure data | ![]() PDB-5wlo: |
Chemicals | ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-GR7: ![]() ChemComp-GOL: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | hydrolase/hydrolase inhibitor / HIV protease / Macrocyclic inhibitors / P1'- P2' ligands / Drug resistance / HYDROLASE / hydrolase-hydrolase inhibitor complex |