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Structure paper

TitleHelix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition.
Journal, issue, pagesEMBO J., Vol. 37, Page 75-88, Year 2018
Publish dateJul 8, 2017 (structure data deposition date)
AuthorsKlum, S.M. / Chandradoss, S.D. / Schirle, N.T. / Joo, C. / MacRae, I.J.
External linksEMBO J. / PubMed:28939659
MethodsX-ray diffraction
Resolution3.12 Å
Structure data

PDB-5wea:
Human Argonaute2 Helix-7 Mutant
Method: X-RAY DIFFRACTION / Resolution: 3.12 Å

Chemicals

ChemComp-IPH:
PHENOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/RNA / Argonaute / RNA binding / RNA silencing / microRNA / HYDROLASE / HYDROLASE-RNA complex

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