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-Structure paper
| Title | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. |
|---|---|
| Journal, issue, pages | PLoS ONE, Vol. 12, Page e0184843-e0184843, Year 2017 |
| Publish date | Mar 22, 2017 (structure data deposition date) |
 Authors | Hall, J. / Brault, A. / Vincent, F. / Weng, S. / Wang, H. / Dumlao, D. / Aulabaugh, A. / Aivazian, D. / Castro, D. / Chen, M. ...Hall, J. / Brault, A. / Vincent, F. / Weng, S. / Wang, H. / Dumlao, D. / Aulabaugh, A. / Aivazian, D. / Castro, D. / Chen, M. / Culp, J. / Dower, K. / Gardner, J. / Hawrylik, S. / Golenbock, D. / Hepworth, D. / Horn, M. / Jones, L. / Jones, P. / Latz, E. / Li, J. / Lin, L.L. / Lin, W. / Lin, D. / Lovering, F. / Niljanskul, N. / Nistler, R. / Pierce, B. / Plotnikova, O. / Schmitt, D. / Shanker, S. / Smith, J. / Snyder, W. / Subashi, T. / Trujillo, J. / Tyminski, E. / Wang, G. / Wong, J. / Lefker, B. / Dakin, L. / Leach, K. |
 External links | PLoS ONE / PubMed:28934246 |
| Methods | X-ray diffraction |
| Resolution | 3.1 - 3.23 Å |
| Structure data |  PDB-5v8o:  PDB-6nao: |
| Chemicals |  ChemComp-ZN:  ChemComp-8ZM:  ChemComp-HOH:  ChemComp-KHM: |
| Source |
|
 Keywords | transferase/transferase inhibitor / cGAS / STING / cGAMP / transferase-transferase inhibitor complex / TRANSFERASE |
homo sapiens (human)