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Title | Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 8083-8102, Year 2017 |
Publish date | May 1, 2017 (structure data deposition date) |
Authors | Patel, S. / Meilandt, W.J. / Erickson, R.I. / Chen, J. / Deshmukh, G. / Estrada, A.A. / Fuji, R.N. / Gibbons, P. / Gustafson, A. / Harris, S.F. ...Patel, S. / Meilandt, W.J. / Erickson, R.I. / Chen, J. / Deshmukh, G. / Estrada, A.A. / Fuji, R.N. / Gibbons, P. / Gustafson, A. / Harris, S.F. / Imperio, J. / Liu, W. / Liu, X. / Liu, Y. / Lyssikatos, J.P. / Ma, C. / Yin, J. / Lewcock, J.W. / Siu, M. |
External links | J. Med. Chem. / PubMed:28929759 |
Methods | X-ray diffraction |
Resolution | 2.45 - 2.96 Å |
Structure data | PDB-5vo1: PDB-5vo2: |
Chemicals | ChemComp-9FS: ChemComp-HOH: ChemComp-9FV: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE Inhibitor / kinase / TRANSFERASE-TRANSFERASE Inhibitor complex |