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TitlecGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
Journal, issue, pagesNature, Vol. 549, Page 394-398, Year 2017
Publish dateFeb 15, 2017 (structure data deposition date)
AuthorsAndreeva, L. / Hiller, B. / Kostrewa, D. / Lassig, C. / de Oliveira Mann, C.C. / Jan Drexler, D. / Maiser, A. / Gaidt, M. / Leonhardt, H. / Hornung, V. / Hopfner, K.P.
External linksNature / PubMed:28902841
MethodsX-ray diffraction
Resolution3.6 Å
Structure data

PDB-5n6i:
Crystal structure of mouse cGAS in complex with 39 bp DNA
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsTRANSFERASE / nucleotidyltransferase / cyclic GMP-AMP synthase / cGAS / DNA-binding / activator DNA / pattern recognition receptor / innate immune response / viral DNA recognition

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