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TitleModulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.
Journal, issue, pagesMAbs, Vol. 9, Page 1306-1316, Year 2017
Publish dateDec 21, 2016 (structure data deposition date)
AuthorsZwolak, A. / Armstrong, A.A. / Tam, S.H. / Pardinas, J.R. / Goulet, D.R. / Zheng, S. / Brosnan, K. / Emmell, E. / Luo, J. / Gilliland, G.L. / Chiu, M.L.
External linksMAbs / PubMed:28898162
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-5ubx:
Crystal structure of a mutant mIgG2b Fc heterodimer in complex with Protein A peptide analog Z34C
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • staphylococcus aureus (bacteria)
KeywordsIMMUNE SYSTEM / PROTEIN A / FC COMPLEX / B-DOMAIN / Z-DOMAIN / IMMUNOGLOBULIN FOLD

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