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TitleTotal Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System.
Journal, issue, pagesCell Chem Biol, Vol. 24, Page 1216-1227.e8, Year 2017
Publish dateFeb 13, 2017 (structure data deposition date)
Authorsvon Tesmar, A. / Hoffmann, M. / Pippel, J. / Fayad, A.A. / Dausend-Werner, S. / Bauer, A. / Blankenfeldt, W. / Muller, R.
External linksCell Chem Biol / PubMed:28890318
MethodsX-ray diffraction
Resolution1.55 Å
Structure data

PDB-5n5d:
Crystal Structure of the O-Methyltransferase TomG from Streptomyces achromogenes involved in Tomaymycin synthesis in complex with SAM
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • streptomyces regensis (bacteria)
KeywordsTRANSFERASE / o-Methyltransferase / tomaymycin / Rossmann-like fold / S-adenosyl methionine

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