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TitleStructure of the Human Mitochondrial Ribosome Studied In Situ by Cryoelectron Tomography.
Journal, issue, pagesStructure, Vol. 25, Issue 10, Page 1574-11581.e2, Year 2017
Publish dateOct 3, 2017
AuthorsRobert Englmeier / Stefan Pfeffer / Friedrich Förster /
PubMed AbstractMitochondria maintain their own genome and its corresponding protein synthesis machine, the mitochondrial ribosome (mitoribosome). Mitoribosomes primarily synthesize highly hydrophobic proteins ...Mitochondria maintain their own genome and its corresponding protein synthesis machine, the mitochondrial ribosome (mitoribosome). Mitoribosomes primarily synthesize highly hydrophobic proteins of the inner mitochondrial membrane. Recent studies revealed the complete structure of the isolated mammalian mitoribosome, but its mode of membrane association remained hypothetical. In this study, we used cryoelectron tomography to visualize human mitoribosomes in isolated mitochondria. The subtomogram average of the membrane-associated human mitoribosome reveals a single major contact site with the inner membrane, mediated by the mitochondria-specific protein mL45. A second rRNA-mediated contact site that is present in yeast is absent in humans, resulting in a more variable association of the human mitoribosome with the inner membrane. Despite extensive structural differences of mammalian and fungal mitoribosomal structure, the principal organization of peptide exit tunnel and the mL45 homolog remains invariant, presumably to align the mitoribosome with the membrane-embedded insertion machinery.
External linksStructure / PubMed:28867615
MethodsEM (subtomogram averaging)
Resolution26.0 Å
Structure data

EMDB-3784:
Structure of the membrane-bound human mitoribosome
Method: EM (subtomogram averaging) / Resolution: 26.0 Å

Source
  • Homo sapiens (human)

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