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-Structure paper
Title | Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 45, Page 8142-8155, Year 2017 |
Publish date | Mar 27, 2017 (structure data deposition date) |
![]() | Mutisya, D. / Hardcastle, T. / Cheruiyot, S.K. / Pallan, P.S. / Kennedy, S.D. / Egli, M. / Kelley, M.L. / Smith, A.V.B. / Rozners, E. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.95 Å |
Structure data | ![]() PDB-5vaj: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-MG: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | hydrolase/rna/dna / Amide-RNA / siRNA / RNA X-ray structure / phosphate modification / RIBONUCLEASE H / amide modified RNA-DNA. / hydrolase-rna-dna complex |